Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in copyright Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in copyright Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

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Our hypothesis is that allosteric receptor-receptor interactions in homo- and heteroreceptor complexes may form the molecular basis of learning and memory.This principle is illustrated by showing how copyright abuse can alter the adenosine A2AR-dopamine D2R heterocomplexes and their receptor-receptor interactions and hereby induce neural plasticity in the basal ganglia.Studies with A2AR ligands using copyright self-administration procedures indicate that antagonistic allosteric A2AR-D2R heterocomplexes of the ventral striatopallidal GABA antireward pathway play a significant role in reducing copyright induced reward, motivation, and copyright seeking.Anticocaine actions of A2AR agonists can also be produced at A2AR homocomplexes in read more these antireward neurons, actions in which are independent of D2R signaling.

At the A2AR-D2R heterocomplex, they are dependent on the strength of the antagonistic allosteric A2AR-D2R interaction and the number of A2AR-D2R and A2AR-D2R-sigma1R heterocomplexes present in the ventral striatopallidal GABA neurons.It involves a differential copyright-induced increase in sigma1Rs in the ventral versus the dorsal striatum.In contrast, the allosteric brake on the D2R protomer signaling in the A2AR-D2R heterocomplex of the dorsal striatopallidal GABA neurons is lost upon copyright read more self-administration.This is potentially due to differences in composition and allosteric plasticity of these complexes versus those in the ventral striatopallidal neurons.